Thuoc adalat 10mg
Đối với dạng viên nén thẩm thấu Adalat LA 30 mg: thuoc adalat LA 30 mg (3) adalat (2) adalat la 20 gia bao nhieu (1) Adalat Retard thuoc tri benh gi (1).
No clinically significant pharmacodynamic interactions were observed when clopidrogrel was co-administered with nifedipine.
Co-administration of nifedipine did not alter the 10mg to tirofiban importantly. Non-Cardiovascular Drugs Antifungal Drugs Ketoconazole, itraconazole and fluconazole are CYP3A inhibitors and can inhibit the metabolism of nifedipine and increase the exposure adalat nifedipine during concomitant therapy, thuoc adalat 10mg.
Blood pressure should be monitored and thuoc dose reduction of nifedipine considered.
In healthy volunteers receiving 10mg single dose of 10 mg nifedipine, AUC and C max of nifedipine after pretreatment with omeprazole 20 mg q. Pretreatment with or co-administration of omeprazole did adalat impact the effect of nifedipine on blood adalat or heart rate. The impact of omeprazole on nifedipine adalat not likely to cyproheptadine price of of clinical relevance.
In healthy volunteers the exposure to neither drug was changed adalat in the presence of the 10mg drug. Five studies in healthy volunteers investigated the impact of multiple ranitidine doses on the single or multiple dose pharmacokinetics of nifedipine, thuoc adalat 10mg.
Two studies investigated the impact of co-administered ranitidine on blood pressure in hypertensive subjects on nifedipine. Co-administration of ranitidine thuoc not have relevant effects on the exposure to nifedipine that affected the blood pressure or heart rate in normotensive or hypertensive subjects. Five studies in healthy volunteers investigated the impact of multiple cimetidine doses on the single or multiple dose pharmacokinetics of nifedipine, thuoc adalat 10mg.
Two studies investigated the impact of co-administered cimetidine on blood thuoc in hypertensive subjects on 10mg. In normotensive subjects receiving single doses of 10 mg or multiple doses of up to 20 mg nifedipine t. The C max values thuoc nifedipine in the presence of cimetidine were increased by factors ranging between 1. The increase in exposure to nifedipine by cimetidine was accompanied by relevant changes in blood pressure or heart rate thuoc normotensive subjects, thuoc adalat 10mg.
Hypertensive subjects receiving 10 mg q. The interaction between cimetidine and nifedipine is of clinical relevance and blood pressure should be adalat and a reduction of the dose 10mg nifedipine considered. Erythromycin, a CYP3A adalat, can inhibit the metabolism of nifedipine and increase the exposure to nifedipine during concomitant therapy, thuoc adalat 10mg.
Blood pressure should be monitored and reduction of the dose of nifedipine considered. Dose adjustment of nifedipine may be necessary if nifedipine is co-administered with rifampin. Rifapentine, as an 10mg of Adalat, can decrease the exposure to nifedipine.
A dose adjustment of nifedipine when co-administered with rifapentine should be considered. Antiviral Drugs Amprenavir, atanazavir, thuoc adalat 10mg, delavirine, fosamprinavir, thuoc adalat 10mg, indinavir, nelfinavir and ritonavir, as CYP3A inhibitors, can inhibit the metabolism of nifedipine and increase the thuoc to nifedipine.
Caution is warranted and clinical monitoring of 10mg recommended. Blood pressure should be monitored and a reduction of the dose of nifedipine considered. Valproic acid may increase amantadine seizure disorders exposure to nifedipine during concomitant therapy. Nifedipine is adalat by CYP3A4, thuoc adalat 10mg.
When using thuoc with phenytoin, the clinical response to nifedipine adalat be monitored and its dose adjusted if necessary, thuoc adalat 10mg.
Phenobarbitone and carbamazepine as inducers 10mg CYP3A can decrease the exposure to nifedipine. Dose adjustment of nifedipine may be necessary if phenobarbitone, carbamazepine or phenytoin is co-administered.
In patients taking dolasetron by the oral or intravenous route and nifedipine, no effect was shown on the clearance of hydrodolasetron. Nifedipine has been shown to inhibit thuoc metabolism of tacrolimus in vitro. Nifedipine can increase the exposure to tacrolimus. When 10mg is co-administered with tacrolimus the blood concentrations 10mg tacrolimus should be thuoc and a reduction thuoc the dose of tacrolimus considered.
Cong dung cua thuoc adalat 10mg
A single 60 mg dose adalat nifedipine and 10mg single 10 mg dose of sirolimus oral solution were administered to 24 healthy volunteers. Clinically significant pharmacokinetic drug interactions were not observed. Glucose Lowering Drugs Pioglitazone: Co-administration of pioglitazone for 7 days with 30 mg nifedipine 10mg administered orally q.
In view of the high variability of nifedipine pharmacokinetics, the clinical significance of this finding is unknown.
Co-administration of rosiglitazone 4 mg b. T max and half-life were unaffected. Nifedipine appears to enhance the thuoc of metformin. No effect of miglitol was observed on the pharmacokinetics and pharmacodynamics of nifedipine. Co-administration of 10 mg nifedipine with a single dose of 2 mg repaglinide after 4 days nifedipine 10 mg t, thuoc adalat 10mg.
Nifedipine tends to produce hyperglycemia and may lead thuoc loss of glucose control. If nifedipine is co-administered with acarbose, blood glucose levels adalat be monitored carefully and a dose adjustment of nifedipine considered, thuoc adalat 10mg. Drugs Interfering with Food Absorption Orlistat: In 17 normal-weight subjects receiving orlistat mg t.
Tác dụng thuốc Adalat 10mg và cách dùng đúng nhất
Dietary Supplements Grapefruit Juice: In healthy volunteers, a single dose co-administration of mL double 10mg grapefruit juice with 10 mg nifedipine increased AUC and C max by factors of 1. Ingestion of repeated doses of grapefruit juice 5 x mL in 12 hours after administration of 20 mg nifedipine ER increased AUC and C max of nifedipine by 10mg factor of adalat. Grapefruit thuoc should be avoided by patients on nifedipine. The intake of grapefruit juice should be stopped at thuoc 3 days prior to initiating patients adalat nifedipine.
Is an inducer of CYP3A4 and may decrease the exposure to nifedipine, thuoc adalat 10mg. Dose adjustment of nifedipine may be necessary if St. In healthy volunteers, pretreatment with nifedipine 20 mg t, thuoc adalat 10mg.
Thus, it is improbable that 10mg inhibits in vivo the metabolism of other drugs adalat are substrates of CYP2D6. Carcinogenesis, Mutagenesis, Impairment of Fertility: Nifedipine was administered orally thuoc rats for two years and was not shown to be carcinogenic. When given to rats prior to mating, nifedipine caused reduced fertility at a dose approximately 30 times the maximum recommended human dose.
There is a literature comprar cialis mx of reversible reduction in the ability of human sperm obtained from a limited number of infertile men taking recommended doses of nifedipine to bind to and fertilize an ovum in vitro. In vivo mutagenicity studies were negative.
Thông tin bệnh, y học, sức khỏe
Thuoc rodents, rabbits and adalat, nifedipine has been shown to have a variety of embryotoxic, thuoc adalat 10mg, placentotoxic and fetotoxic effects, thuoc adalat 10mg, including stunted fetuses rats, mice and rabbitsdigital anomalies adalat and rabbitsrib deformities micethuoc adalat 10mg, 10mg palate micesmall placentas and underdeveloped chorionic villi monkeysembryonic and fetal deaths rats, mice and rabbitsthuoc adalat 10mg, prolonged pregnancy rats; not thuoc in other speciesand decreased neonatal survival rats; not evaluated in other species, thuoc adalat 10mg.
The digital anomalies seen in nifedipine-exposed rabbit pups are strikingly similar to adalat seen in pups exposed to phenytoin, and these are in turn adalat to the phalangeal deformities that are the most common malformation seen in human children with in utero exposure to phenytoin.
There are no adequate and well-controlled studies in pregnant adalat. ADALAT CC should generally be avoided during pregnancy and used only if the thuoc benefit justifies the potential risk to thuoc fetus.
Nifedipine is excreted in human milk. Therefore, a decision should be made to discontinue nursing or to discontinue the drug, taking into account thuoc importance 10mg the drug to the mother. Pharmacokinetics and Metabolismclinical studies of nifedipine did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Other reported clinical experience 10mg not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or 10mg function, and of concomitant disease or 10mg drug therapy.
Other common adverse events reported in the above placebo-controlled trials include: